Welcome to the Kovalski lab in the Department of Biochemistry and Biophysics as well as the Lineberger Comprehensive Cancer Center at UNC! We focus on decoding the hidden post-transcriptional regulatory networks that cancer cells exploit to survive and thrive. Cancer research that relies on traditional genomics approaches misses the critical impact of selective translational control in sculpting the cancer proteome. We map how RNA-protein interactions maintain precise oncogenic protein dosage during stress, oncogenic transformation, and disease progression. Our approach—from CRISPR screens and RNA structure mapping to proteomics and mouse models—reveals fundamental principles of gene regulation and exposes novel cancer therapeutic vulnerabilities.

Our lab is committed to fostering an open and collaborative environment where lab members develop both scientific expertise as well as the leadership and communication skills necessary for their chosen scientific career paths. The multifaceted, interdisciplinary nature of our research offers diverse opportunities to align projects with trainees' interests and strengths. Lab members are encouraged to engage with the broader scientific community at UNC and beyond through conferences, outreach, and professional development opportunities. We value the unique perspectives each person brings and actively cultivate an inclusive space where all voices contribute to scientific discovery.